Clinical use of unfractionated heparin therapy in children: Time for change?: Research paper

F Newall; V Ignjatovic; L Johnston; R Summerhayes; G Lane; N Cranswick; P Monagle

Journal article

Clinical use of unfractionated heparin therapy in children: Time for change?: Research paper

F Newall, V Ignjatovic, L Johnston, R Summerhayes, G Lane, N Cranswick, P Monagle

British Journal of Haematology | Published : 2010

DOI: 10.1111/j.1365-2141.2010.08302.x

Abstract

Paediatric recommendations for unfractionated heparin (UFH) management are extrapolated from adult trials, a practice that may contribute to the inferior UFH-related outcomes in children compared to adults. This is the first study to determine UFH concentration in a population of children and correlated UFH concentration with measures of UFH effect. Correlation coefficients between protamine titration (concentration) and activated partial thromboplastin time (APTT), anti- activated factor X (Xa) assay and thrombin clotting time (effect) were 0·59, 0·46 and 0·52 respectively. A protamine titration level of 0·2-0·4 iu/ml in children was not equivalent to an anti-Xa assay of 0·35-0·7 iu/ml but ..

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University of Melbourne Researchers

Fiona Newall Author

Vera Ignjatovic Author

Paul Monagle Author

Related Projects (1)

Age-related response to heparin in children.

Unfractionated Heparin (UFH) is the most commonly used anticoagulant (blood thinning drug) in children. Despite this, the clinical evidence,..

Grants

Awarded by NHMRC

Funding Acknowledgements

This project was supported by an NHMRC Research Grant #454385. Dr Ignjatovic is supported by the Sanofi-Aventis Clinical Research Fellowship. Dr Fiona Newall held an Australian Postgraduate Award.